This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignees: University of Pittsburgh, Wake Forest University. Active years: 2015.
Company Filing History:
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Years Active: 2015
Title: The Innovative Contributions of Mauro Tiso
Introduction
Mauro Tiso is a notable inventor based in Bethesda, MD (US). He has made significant contributions to the field of biomedical research, particularly in the development of blood substitutes. His work focuses on the unique properties of neuroglobin, a protein that plays a crucial role in oxygen transport.
Latest Patents
Mauro Tiso holds a patent for a groundbreaking invention titled "Five-coordinate neuroglobin and use thereof as a blood substitute." This patent describes a mutant form of human neuroglobin (H64L) that exhibits a stable five-coordinate geometry. This variant reduces nitrite to nitric oxide approximately 2000 times faster than the wild type neuroglobin. Additionally, five-coordinate neuroglobin is capable of binding and releasing oxygen, making it a promising candidate for use as a blood substitute. The patent outlines methods for replacing blood and enhancing oxygen delivery to tissues by administering a therapeutically effective amount of this neuroglobin variant.
Career Highlights
Throughout his career, Mauro Tiso has worked with prestigious institutions such as the University of Pittsburgh and Wake Forest University. His research has garnered attention for its potential applications in medical treatments and blood replacement therapies.
Collaborations
Mauro Tiso has collaborated with esteemed colleagues, including Daniel B Kim-Shapiro and Mark Thomas Gladwin. These partnerships have contributed to the advancement of research in the field of neuroglobin and its applications.
Conclusion
Mauro Tiso's innovative work in the development of five-coordinate neuroglobin represents a significant advancement in the search for effective blood substitutes. His contributions to biomedical research continue to inspire future innovations in the field.