Introduction: Maurice M Klee, an accomplished inventor based in Fairfield, Connecticut, has made significant contributions to the field of neural activity modification through his innovative patents. With a remarkable portfolio of 20 patents, Klee's work primarily focuses on developing advanced techniques and tools for electrophysiology that are relevant to various medical and research applications.

Latest Patents: Among Klee's latest patents is a groundbreaking method for modifying neural activity by applying electrical current to neural tissue. This disclosure covers a range of stimulation procedures, including transcranial DC stimulation (tDCS), transcranial AC stimulation (tACS), transcranial random noise stimulation (tRNS), deep brain stimulation (DBS), and transcutaneous electrical nerve stimulation (TENS). Klee's innovative approach utilizes a computed charge distribution on the bounding surface of sulci filled with cerebrospinal fluid (CSF) to improve electrode placement. This method enhances the efficacy of the electrical currents applied by employing sensors to gauge the charge around each pixel in the sulcus.

Another significant patent of Klee's involves the development of improved computer-implemented tools for modeling and simulating spatial charge distributions within electrophysiological systems. The enhancements focus on three areas: calculating free and bound charges via solid angles, employing flattened calculation cells, and incorporating separate spatial charge distributions for bound and free charges to consider varying dielectric constants in the systems. These advancements can be utilized individually or in combination, offering flexibility for varied applications.

Career Highlights: Klee's career has been marked by a commitment to innovation in the realm of neuroscience and electrophysiology. His work has led to the advancement of understanding and manipulating neural activity through electrical means. His patents showcase a blend of engineering, mathematics, and neurological science, making him a pivotal figure in this intricate field.

Collaborations: Throughout his career, Klee has collaborated with esteemed colleagues, including Gary L Cochran and James E Dawson. Their collective expertise has contributed to a range of innovations and improvements in the applications of neural stimulation and modeling.

Conclusion: Maurice M Klee stands out as a prominent inventor whose work continues to push the boundaries of modern neuroscience. With his suite of patents and collaborative spirit, he has left an indelible mark on the field of neural modifications, promising ongoing advancements in the treatment of neurological conditions and enhancing our understanding of brain function.

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