This inventor holds 2 USPTO granted patents, plus 2 CIPO patents and 3 EPO patents. Top assignee: Bruker-Franzen Analytik Gmbh. Active years: 1996-1997.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1996-1997
Title: Matthias Wilm: A Pioneer in RNA Interference Research
Introduction
Matthias Wilm is a notable inventor in the field of molecular biology, particularly recognized for his contributions to RNA interference (RNAi). His innovative work has significantly advanced our understanding of gene silencing mechanisms in various organisms. Despite having no patents to his name, his research has laid the groundwork for future developments in genetic engineering and therapeutic applications.
Latest Patents
Wilm's latest research focuses on RNA interference mediating small RNA molecules. He has demonstrated that double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing through RNAi. Using a Drosophila in vitro system, he has shown that 19-23 nucleotide short RNA fragments serve as the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are produced by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3' ends effectively mediate target RNA cleavage in the lysate, with the cleavage site located near the center of the region spanned by the guiding siRNA. Furthermore, Wilm provides evidence that the direction of dsRNA processing influences whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
Career Highlights
Throughout his career, Matthias Wilm has worked with prestigious institutions, including the European Molecular Biology Laboratory and the Max Planck Society for the Advancement of Science. His research has contributed to the understanding of RNAi, which has implications for gene therapy and biotechnology.
Collaborations
Wilm has collaborated with prominent scientists in the field, including Thomas Tuschl and Sayda Elbashir. These collaborations have further enriched his research and expanded the impact of his findings in the scientific community.
Conclusion
Matthias Wilm's contributions to RNA interference research have been instrumental in advancing molecular biology. His innovative approaches and collaborative efforts continue to influence the field, paving the way for future discoveries in gene silencing and therapeutic applications.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile