Matthew Kalo

Title: Inventor Matthew Kalo – Innovator in Therapeutic Peptide Conjugation

Introduction

Matthew Kalo, an innovative inventor based in San Francisco, CA, has made a significant impact in the field of therapeutic peptides through his groundbreaking work. With a career dedicated to enhancing pharmaceutical formulations, Kalo holds a patented invention that exemplifies his contributions to biochemistry and medicinal chemistry.

Latest Patents

Kalo's notable patent is entitled "One pot desialylation and glycopegylation of therapeutic peptides." This invention introduces conjugates between peptides and PEG (polyethylene glycol) moieties. The technology described in the patent allows for these conjugates to be linked via an intact glycosyl linking group, which is covalently attached to both the peptide and the modifying group. Kalo's innovation enables the formation of conjugates from glycosylated and unglycosylated peptides through the action of a glycosyltransferase, which ligates a modified sugar moiety onto respective amino acids or glycosyl residues on the peptide. Additionally, the patent outlines various pharmaceutical formulations that include these conjugates and methods for their preparation.

Career Highlights

Kalo has spent a significant part of his career at Novo Nordisk A/S, a company renowned for its commitment to healthcare and innovation in diabetes care, obesity treatment, and other serious chronic conditions. His expertise has contributed to advancing therapeutic strategies and enhancing patient outcomes through improved drug formulations.

Collaborations

Throughout his work, Kalo has collaborated with esteemed colleagues such as Shawn DeFrees and David A. Zopf, further amplifying the impact of his research efforts. These collaborations reflect a commitment to teamwork in the pursuit of innovative solutions that can benefit the pharmaceutical industry and patients alike.

Conclusion

As an inventor, Matthew Kalo stands at the forefront of innovation in therapeutic peptide conjugation. His patented invention not only showcases his scientific prowess but also highlights the potential for advancements in pharmaceutical formulations that can lead to more effective treatments. Kalo's contributions underscore the vital role of inventors in shaping the future of medicine and improving health outcomes for individuals worldwide.