Matheus Hubertus Noteborn

Title: Matheus Hubertus Noteborn: Innovator in Viral Research

Introduction

Matheus Hubertus Noteborn is a notable inventor based in Leiden, Netherlands. He has made significant contributions to the field of virology, particularly in the development of vaccines and methods for treating infections caused by the Chicken Anemia Virus (CAV). With a total of four patents to his name, Noteborn's work has had a substantial impact on poultry health and disease prevention.

Latest Patents

Noteborn's latest patents include innovative approaches to combatting CAV. One of his key inventions involves the use of chicken anemia virus mutants and vaccines. This patent describes how the coding information for three putative CAV proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. The immunogenic properties of these proteins were analyzed by inoculating them into chickens. The results indicated that the expression of at least two CAV proteins, specifically VP1 and VP2, is necessary to induce sufficient protection in chickens against CAV challenges. This research highlights the potential of recombinant CAV proteins produced by baculovirus vectors as a sub-unit vaccine against CAV infections.

Another significant patent focuses on methods and compositions for inducing apoptosis in tumor cells. This invention describes novel proteins of CAV and compositions for preventing or treating infections with the virus. It emphasizes the development of vaccines that are less pathogenic than the CAV itself while still leading to the production of neutralizing antibodies in immunized animals. Additionally, the invention provides antibodies and test kits for the detection of CAV, as well as recombinant DNA molecules derived from CAV for vaccine development.

Career Highlights

Throughout his career, Matheus Hubertus Noteborn has worked with various companies, including Leadd B.V. and Aesculaap B.V. His research has been pivotal in advancing the understanding of CAV and developing effective vaccines to protect poultry from this virus. Noteborn's innovative approaches have contributed to the field of virology and have the potential to improve animal health on a larger scale.

Collaborations

Noteborn has collaborated with notable colleagues such as Guus Koch and Gerben F De Boer. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the impact of their research in the field of viral infections and vaccine development.

Conclusion