Masashi Okamoto

Title: Masashi Okamoto and a Cell Culture Method for Blood-Brain Barrier Models.

Introduction

Masashi Okamoto is an inventor associated with Yamaguchi University in Yamaguchi, Japan. His patent work includes a method and device designed to support the mass production of an in vitro, three-layer blood-brain barrier (BBB) model.

Latest Patents

The supplied patent information identifies one patent for Okamoto: “Cell Culture Method and Cell Culture Device Used with Cell Culture Method.” The invention describes a process for culturing vascular endothelial cells, pericytes, and astrocytes in a configuration that models the three-layer BBB.

The method involves injecting suspended cell culture medium onto the outer surface of a porous membrane in a cell culture insert and culturing astrocytes in the medium. The insert is then inverted so pericytes can be seeded and cultured. Next, temperature-sensitive vascular endothelial cells embedded in a temperature-sensitive gel are seeded and cultured, after which the gel is melted. The approach is intended to make production of the three-layer BBB models more efficient and scalable. Okamoto’s reported patent count is 1 patent.

Career Highlights

Okamoto’s listed affiliation is Yamaguchi University. The patent reflects work in cell culture technology, particularly methods for constructing in vitro models that include multiple cell types associated with the blood-brain barrier.

Collaborations

Susumu Fujikawa is identified as Okamoto’s coworker. The supplied information does not specify Fujikawa’s role in the patent or the nature of their collaboration.

Conclusion

Masashi Okamoto’s reported invention offers a structured cell-culture process for producing three-layer blood-brain barrier models, with the goal of enabling their more efficient mass production.