Masao Umezaki

Title: The Innovative Contributions of Masao Umezaki

Introduction

Masao Umezaki is a notable inventor based in Hekinan, Japan. He has made significant contributions to the field of pharmaceutical excipients, particularly through his innovative methods for producing starch granules. His work has implications for the development of orally disintegrating tablets, which are essential in modern medicine.

Latest Patents

Umezaki holds a patent for a method for producing starch granules, which are suitable as excipients for orally disintegrating tablets. This method involves fluidized bed granulation, where a starch paste is sprayed in small amounts while a β-starch is fluidized using an air-fluidized bed. The process includes fluidized bed drying at a temperature equal to or higher than the gelatinization temperature of the β-starch. This results in starch granules that exhibit a high degree of gelatinization, enhancing their effectiveness as excipients. Notably, these granules provide satisfactory oral disintegratability and breaking strength, eliminating the need for additional auxiliary excipients such as saccharides or crystalline cellulose.

Career Highlights

Masao Umezaki is associated with Japan Corn Starch Co., Ltd., where he has been instrumental in advancing the company's research and development efforts. His innovative approach to starch granule production has positioned him as a key figure in the pharmaceutical excipient industry.

Collaborations

Umezaki has collaborated with notable colleagues, including Hiroshige Murase and Toshio Uno. Their combined expertise has contributed to the successful development of new methodologies in the field.

Conclusion

Masao Umezaki's contributions to the production of starch granules have significantly impacted the pharmaceutical industry. His innovative methods enhance the formulation of orally disintegrating tablets, showcasing the importance of research and development in creating effective medical solutions.