Location History:
- Tsuchiura, JP (1982 - 1983)
- Ibaraki, JP (1986)
Company Filing History:
2 out of 1,001 
1 out of 299 Years Active: 1982-1986
Title: Masami Soejima: An Innovator in Biochemistry
Introduction
Masami Soejima, an accomplished inventor based in Tsuchiura, Japan, is renowned for his significant contributions to the field of biochemistry. With a total of three patents to his name, Soejima has made profound advancements that enhance our understanding of enzymes and insulin synthesis.
Latest Patents
One of Soejima's most noteworthy patents is a novel alkaline protease. This enzymatic innovation has a molecular weight of 30,000, as determined by a gel filtration method using Sephadex G-75. The enzyme exhibits an isoelectric point of 5.3 and is optimized for its esterase activity at a pH of 8.5, while showing optimal amidase activity at pH 9.0. It specifically hydrolyzes the ester and amide bonds derived from the carboxyl group of L-lysine, and its activity is inhibited by diisopropyl phosphofluoride, tosyl-L-lysine chloro-methyl ketone, and phenylmethylsulfonyl chloride. Importantly, this protease is preferably produced by microorganisms belonging to the genus Achromobacter.
Another significant patent involves the semi-synthesis of human insulin, detailing a process for preparing B30-threonine-insulin. This process includes reacting a des-B30-insulin with an excess of a threonine derivative in the presence of an enzyme that specifically acts on lysine carbonyl in peptide bondings, produced by Achromobacter lyticus M 497-1.
Career Highlights
Throughout his career, Soejima has worked with reputable companies such as Shionogi & Company Limited and Wako Pure Chemical Industries, Inc. His dedication to research and innovation has been recognized within the biochemistry community, contributing to significant advancements in enzyme applications and therapeutic processes.
Collaborations
Masami Soejima has collaborated with fellow researchers, including Takeharu Masaki and Kazuyuki Morihara. These partnerships highlight the collaborative spirit in scientific innovation, leading to the development of novel biotechnological approaches.
Conclusion
In summary, Masami Soejima's contributions to biochemistry, highlighted by his innovative patents, demonstrate his significant role in the field. His work not only advances our scientific understanding but also sets the stage for future innovations that can benefit a variety of applications in health and industry.