Location History:
- Hiromachi, JP (1981)
- Tokyo, JP (1988 - 1991)
Company Filing History:
3 out of 613 
1 out of 1,432 
Years Active: 1981-1991
Title: Masafumi Yoshimoto: Innovator in Dihydropyridine Derivatives
Introduction
Masafumi Yoshimoto is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of medicinal chemistry, particularly in the development of dihydropyridine derivatives. With a total of 3 patents to his name, his work has implications for treating various circulatory and coronary disorders.
Latest Patents
Yoshimoto's latest patents focus on 1,4-dihydropyridine derivatives. One of his notable inventions is the 1,4-Dihydro-6-methyl-4-(substituted phenyl)pyridine-3,5-dicarboxylic acid esters, which contain an amino group at the 2-position and at least one nitrooxy group in one of the ester groups. These compounds exhibit valuable activities, including antihypertensive and Ca.sup.++ -blocking properties, making them useful for treating circulatory and coronary disorders. They can be synthesized through the condensation of appropriate substituted acetic acid esters. Another significant patent involves 2-(Amino or methyl)-6-(methyl or amino)-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters, which feature a specific class of heterocyclic groups as the alcohol moiety. Similar to his previous work, these compounds also demonstrate antihypertensive and Ca.sup.++ -blocking activities and can be prepared by condensing appropriate substituted benzylideneacetoacetic acid esters with amidinoacetic acid esters.
Career Highlights
Throughout his career, Masafumi Yoshimoto has worked with notable companies such as Sankyo Company, Limited and Ube Industries, Inc. His experience in these organizations has allowed him to refine his expertise in pharmaceutical innovations and contribute to the advancement of medical treatments.
Collaborations
Yoshimoto has collaborated with esteemed colleagues, including Hiroyuki Koike and Hiroshi Nishino. These partnerships have fostered a collaborative environment that has led to significant advancements in their field.
Conclusion
Masafumi Yoshimoto's contributions to the development of dihydropyridine derivatives highlight his innovative spirit and dedication to improving medical treatments. His patents reflect a