Company Filing History:
1 out of 4,446 
1 out of 29 Years Active: 1995
Title: The Innovative Contributions of Mary S. Kasher
Introduction
Mary S. Kasher is a notable inventor based in Indianapolis, Indiana. She has made significant contributions to the field of biochemistry, particularly in the immobilization of biologically active molecules. Her innovative work has implications for various applications, including affinity chromatography and assay systems.
Latest Patents
Mary S. Kasher holds a patent for the immobilization of biologically active molecules by changing the oxidation state of a transition metal ion. In her patent, a chelating agent is covalently bonded to a biologically active molecule, such as an enzyme or antibody. The biologically active molecule is then contacted with a support containing a bound transition metal ion, which is chelated by the chelating agent. The oxidation state of the metal ion is altered through treatment with an oxidizing or reducing agent, resulting in a kinetically inert oxidation state that immobilizes the biologically active molecule on the support. The transition metal ions used in her work include Co(II), Cr(II), and Ru(III), which can be transformed into Co(III), Cr(III), or Ru(II), respectively. The chelating agents she utilized include iminodiacetic acid, nitrilotriacetic acid, and various others, allowing for the immobilization of multiple biologically active molecules at a metal ion site.
Career Highlights
Throughout her career, Mary S. Kasher has worked with prominent companies such as Eli Lilly and Company and Hybritech Incorporated. Her experience in these organizations has contributed to her expertise in the field of biochemistry and patent development.
Collaborations
Mary has collaborated with notable individuals in her field, including Leslie D. Anderson and James A. Cook. These collaborations have further enriched her work and expanded her contributions to the scientific community.
Conclusion
Mary S. Kasher's innovative work in the immobilization of biologically active molecules has made a significant impact in the field of biochemistry. Her contributions continue to influence various applications in research and industry.