Mary Kleppe

Title: Mary Kleppe: Innovator in Lyophilization Methods

Introduction

Mary Kleppe is a notable inventor based in Milford, CT (US), recognized for her contributions to the field of lyophilization methods. With a total of four patents to her name, she has made significant advancements in the preparation of protein formulations for long-term storage.

Latest Patents

Her latest patents focus on achieving a target residual moisture content for lyophilized drug products. The methods she developed aim to enhance the stability of protein formulations during storage at room temperature or refrigeration. Specifically, her applications provide techniques to obtain a target percentage of residual moisture, such as 3-5%. The secondary drying process can be controlled under a rate of desorption at temperatures similar to the primary drying shelf temperature. Alternatively, her methods allow for lyophilization without a distinct secondary drying step.

Career Highlights

Mary has worked with prominent companies in the pharmaceutical industry, including Regeneron Pharmaceuticals, Inc. Her experience in these organizations has contributed to her expertise in lyophilization and drug formulation.

Collaborations

Some of her notable coworkers include Xiaolin Tang and Ravi Chari, who have collaborated with her on various projects related to her patents.

Conclusion

Mary Kleppe's innovative work in lyophilization methods has significantly impacted the pharmaceutical industry, particularly in the storage and stability of protein formulations. Her contributions continue to pave the way for advancements in drug product development.