Mary Jo Steele Fackler

Title: Mary Jo Steele Fackler and Breast Cancer Methylation Research

Introduction

Mary Jo Steele Fackler is an inventor associated with Johns Hopkins University in Hunt Valley, Maryland. Her patent work concerns genome-wide methylation analysis and its potential to identify breast cancer markers linked to hormone receptor status and risk of recurrence.

Latest Patents

Fackler is named on one patent, titled “Genome-wide methylation analysis and use to identify genes specific to breast cancer hormone receptor status and risk of recurrence.” The research described in the patent analyzed 103 primary invasive breast cancers and 21 normal breast samples using an array that examined 27,578 CpG loci. It identified 40 loci with methylation patterns specific to either estrogen receptor-positive or estrogen receptor-negative tumors, and validated those findings using an independent dataset from The Cancer Genome Atlas. The work also identified 100 methylated CpG loci associated with disease progression. The patent describes arrays containing subtype-specific loci and their potential use in breast cancer diagnosis and treatment. Fackler’s record includes 1 patent.

Career Highlights

Fackler’s listed patent reflects research applying genome-wide methylation analysis to questions of breast cancer biology and clinical assessment. The findings point to potential molecular markers for distinguishing tumor subtypes and evaluating disease progression.

Collaborations

The patent lists Kala Visvanathan and Peng Huang among Fackler’s coworkers. The work is associated with Johns Hopkins University.

Conclusion

Mary Jo Steele Fackler’s patent connects methylation research with the search for breast cancer markers that may support subtype identification, diagnosis, and assessment of recurrence risk.