Mary E Brown

Title: Mary E. Brown: Innovating Electrochemical Diagnostics in Indianapolis, IN

Introduction

Mary E. Brown, an inventive mind located in Indianapolis, Indiana, has made significant contributions to the field of electrochemical diagnostics with her two notable patents. Her work has focused on creating diagnostic kits and methods that enable precise detection of analytes in various samples. Through her innovative mindset, Brown has played a crucial role in advancing medical technology.

Latest Patents

Brown's recent patents include the following groundbreaking inventions:

1. **Electrochemical Enzyme Assay** - This patent describes a diagnostic kit, method, and apparatus designed for electrochemically determining the presence or concentration of an analyte in a sample. The process involves forming a mixture that includes the sample, an enzyme acceptor polypeptide, an enzyme donor polypeptide, and a labeled substrate. The active enzyme complex formed reacts to the analyte's presence, hydrolyzing the substrate and generating an electroactive label. This label can be oxidized at an electrode's surface, allowing for measurement of the current and correlation to the analyte's concentration.

2. **Electrochemical Enzymatic Complementation Immunoassay** - This invention provides a method for determining analyte concentration by using a combination of sample components, including specific enzyme-donor polypeptides linked to an analyte analog and a labeled substrate. The competitive binding of the analyte and enzyme-donor polypeptide conjugates to the specific antibody enables the formation of an active enzyme complex, which similarly allows for the determination of the analyte concentration through oxidization and current measurement.

Career Highlights

Throughout her career, Mary E. Brown has collaborated with prominent companies such as Boehringer Mannheim GmbH and Roche Diagnostics GmbH. Her experience in these organizations has contributed immensely to her expertise and innovative developments in the field of diagnostics.

Collaborations

Mary has had the opportunity to work alongside esteemed colleagues, including Lance Scott Kuhn and Robert J. McEnroe. These collaborations have further enriched her research and resulted in advancements in her inventions.

Conclusion

Mary E. Brown's contributions to the world of electrochemical diagnostics showcase her dedication to innovation and her role as a leader in medical technology. Her patents not only reflect her inventive spirit but also highlight the importance of collaboration in achieving breakthroughs in the field. Brown's work will potentially pave the way for improved diagnostic methods, benefitting countless lives.