This inventor holds 2 USPTO granted patents. Top assignee: University of Illinois. Active years: 2006-2009.
Company Filing History:
Years Active: 2006-2009
Title: Innovations of Mary A Schuler in Membrane Scaffold Proteins
Introduction
Mary A Schuler is a prominent inventor based in Urbana, IL (US), known for her significant contributions to the field of membrane scaffold proteins. With a total of 2 patents, her work focuses on developing innovative solutions that enhance the stability and functionality of membrane proteins.
Latest Patents
Schuler's latest patents revolve around the creation of membrane scaffold proteins (MSP) that assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles. These particles preserve the native structure and function of the proteins, offering improvements over traditional liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. This bilayer structure allows for the manipulation of incorporated proteins in solution or on solid supports, facilitating various surface-sensitive techniques such as scanning probe microscopy and surface plasmon resonance. The robust nanoscale particles maintain the integrity and biological activity of the incorporated proteins, thereby aiding pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.
Career Highlights
Mary A Schuler is affiliated with the University of Illinois, where she continues to advance her research in membrane proteins. Her innovative approaches have garnered attention in the scientific community, contributing to the understanding and application of membrane proteins in various fields.
Collaborations
Some of her notable coworkers include Stephen G Sligar and Timothy H Bayburt, who have collaborated with her on various research projects related to membrane scaffold proteins.
Conclusion
Mary A Schuler's work in the development of membrane scaffold proteins represents a significant advancement in the field of biochemistry. Her innovative solutions are paving the way for new research and applications in drug discovery and biological research.