This inventor holds 1 USPTO granted patent. Top assignee: Meselex, Inc.. Active years: 2017.
Company Filing History:
Years Active: 2017
Title: Martin Wessendorf: Innovator in Neuropathic Pain Management
Introduction
Martin Wessendorf is a notable inventor based in Saint Paul, MN (US). He has made significant contributions to the field of neuropathic pain management through his innovative research and patent.
Latest Patents
Wessendorf holds a patent titled "Prevention or attenuation of neuropathic pain by bile acids." This patent discusses methods for reducing or abolishing neuropathic pain in both humans and animals. His research highlights the administration of the apoptosis inhibitor tauroursodeoxycholic acid (TUDCA), which has been shown to greatly reduce neuronal loss and the increase in glia. Additionally, it partially reverses spinal nerve ligation (SNL)-induced mechanical hypersensitivity. The findings indicate that the serotonergic (5-HT) neurons decreased by 35% ipsilateral to SNL, and the density of 5-HT immunoreactive varicosities in the superficial dorsal horn of the spinal cord was lower on the same side. The remaining RVM 5-HT neurons after SNL appeared to facilitate nociception. Treatment with the 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), significantly increased mechanical withdrawal thresholds in rats that had undergone SNL. Wessendorf's research suggests that nerve injury induces the death of antinociceptive RVM neurons, which can be reduced or abolished by TUDCA, shifting the balance of descending control from pain inhibition to pain facilitation.
Career Highlights
Wessendorf is currently associated with Meselex, Inc., where he continues to advance his research in pain management. His work has garnered attention for its potential impact on treating neuropathic pain, a condition that affects many individuals.
Collaborations
Wessendorf collaborates with notable colleagues, including Mai Lan Leong and Clifford Steer, who contribute to his research efforts and innovations in the field.
Conclusion
Martin Wessendorf's contributions to neuropathic pain management through his patent and research are significant. His innovative approaches may lead to improved treatments for those suffering from this challenging condition.