Marko Zlicar

Title: Marko Zlicar: Innovator in Pharmaceutical Chemistry

Introduction

Marko Zlicar is a notable inventor based in Celje, Slovenia, recognized for his contributions to pharmaceutical chemistry. With a total of five patents to his name, Zlicar has made significant advancements in the synthesis of important pharmaceutical compounds. His work primarily focuses on improving the efficacy and purity of various drug formulations.

Latest Patents

Zlicar's latest patents include a process for preparing amorphous rosuvastatin calcium, which is a pure form of the compound that is substantially free from alkali metal impurities. This innovative process involves the hydrolysis of C-Calkyl esters of rosuvastatin, particularly the tert-butyl ester, using organic nitrogen bases in the presence of water. The resulting rosuvastatin salt is then converted with a source of calcium to isolate rosuvastatin calcium, which is crucial for treating conditions such as hyperlipidemia and hypercholesterolemia. Another significant patent relates to the synthesis of β-aminobutyryl substituted compounds, which are essential in modern drug chemistry due to their structural moieties.

Career Highlights

Throughout his career, Zlicar has worked with prominent companies in the pharmaceutical industry, including Lek Pharmaceuticals D.d. and his own venture, Zlicar, Marko. His expertise in drug synthesis and formulation has positioned him as a valuable asset in the field of pharmaceutical research and development.

Collaborations

Zlicar has collaborated with notable professionals in the industry, including Zdenko Casar and Damjan Sterk. These collaborations have further enhanced his research capabilities and contributed to the successful development of his patented processes.

Conclusion

Marko Zlicar's innovative work in pharmaceutical chemistry has led to significant advancements in drug formulation and synthesis. His contributions continue to impact the field positively, showcasing the importance of innovation in healthcare.