Company Filing History:
Years Active: 2013
Title: The Innovative Mind of Mark Spano
Introduction
Mark Spano is a notable inventor based in Scottsdale, Arizona. He has made significant contributions to the field of neuroscience through his innovative patent. His work focuses on understanding the mechanisms of epileptogenesis, which is crucial for developing therapeutic interventions.
Latest Patents
Mark Spano holds a patent for a "Method and system for detecting epileptogenesis." This patent describes a sophisticated approach to tracking neuronal excitation and inhibition in the hippocampal CA1 network during a latent period. The method identifies biomarkers such as a sustained increase in the firing rate of excitatory postsynaptic field activity, coupled with a decrease in inhibitory postsynaptic field activity. The findings reveal characteristic shapes in the mean amplitude profiles of both fEPSP and fEPSP field potential activity during the latent period. Additionally, the research indicates that both excitatory and inhibitory CA1 field activity firing rates follow a circadian rhythm that changes during epileptogenesis. An important biomarker identified is a shift in the circadian rhythm of core body temperature. The therapeutic measures proposed can include thermal, chemical, or electrical modulation, either in an open or closed-loop process.
Career Highlights
Mark Spano is affiliated with the University of Florida Research Foundation, Incorporated. His work has been instrumental in advancing the understanding of epilepsy and its underlying mechanisms. His innovative approach has the potential to lead to new therapeutic strategies for managing epilepsy.
Collaborations
Mark has collaborated with notable colleagues such as Sachin S Talathi and Dong-Uk Hwang. Their combined expertise contributes to the depth and impact of their research in the field of neuroscience.
Conclusion
Mark Spano's contributions to the field of neuroscience through his patent on detecting epileptogenesis highlight his innovative spirit and dedication to advancing medical science. His work not only enhances our understanding of epilepsy but also paves the way for future therapeutic developments.