Location History:
- Boston, MA (US) (1988)
- Brookline, MA (US) (1991)
Company Filing History:
Years Active: 1988-1991
Title: Mark S Pasternack: Innovator in Cytotoxic T Lymphocyte Research
Introduction
Mark S Pasternack is a notable inventor based in Brookline, MA (US). He has made significant contributions to the field of immunology, particularly in the study of cytotoxic T lymphocytes. His work has led to the development of innovative methods and technologies that enhance our understanding of immune responses.
Latest Patents
Mark S Pasternack holds 2 patents. His latest patents include "Cytotoxic T lymphocyte serine esterase and method for stimulation" and "Antibodies, nucleic acid sequences, and methods for inhibition of lysis for a novel serine esterase produced by both murine and human cytotoxic T lymphocytes." These patents focus on a serine esterase with an apparent molecular weight of approximately 28,000-31,000, as determined by SDS gel electrophoresis under reducing conditions, and exhibit trypsin-like activity. The inhibition of this esterase correlates with the inhibition of the cells' cytolytic activity, making it a valuable target for immunosuppression and the modulation of T lymphocyte activity.
Career Highlights
Mark S Pasternack is affiliated with the Massachusetts Institute of Technology, where he continues to advance research in immunology. His work has been instrumental in isolating and characterizing a novel serine esterase produced by cytotoxic T lymphocytes. This protein appears to be membrane-bound and has a reduced apparent molecular weight of about 28,000 daltons. The implications of his research extend to both in vivo and in vitro applications, particularly in the development of antibodies and the inhibition of cytolytic activity by T lymphocytes.
Collaborations
Mark has collaborated with notable colleagues, including Herman N Eisen and Herman S Eisen. Their combined expertise has contributed to the advancement of research in the field of immunology.
Conclusion
Mark S Pasternack is a distinguished inventor whose work in cytotoxic T lymphocyte research has led to significant advancements in immunology. His patents and ongoing research continue to influence the field and provide valuable insights into immune system modulation.
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