Mark S Caddle

Title: Mark S Caddle: Innovator in Replication Initiator Protein Complex

Introduction

Mark S Caddle is a notable inventor based in Woodside, CA (US). He has made significant contributions to the field of molecular biology, particularly in the development of a replication initiator protein complex. His work has implications for understanding cell division and developing therapeutic modalities.

Latest Patents

Mark S Caddle holds a patent for a replication initiator protein complex and methods of use thereof. This complex is designed for eukaryotic cells and includes protein fractions of approximately 60 kD and 100 kD in size. The 60 kD fraction, named RIP60, is primarily active in origin-specific DNA binding, while the 100 kD fraction, named RIP100, functions mainly as a DNA helicase. The protein complex is active only during the S phase of the cell cycle, making it a valuable target for diagnostic and therapeutic applications against pathogens that rely on cell division.

Career Highlights

Throughout his career, Mark S Caddle has worked with prestigious institutions such as The Rockefeller University and the University of Vermont. His research has focused on the mechanisms of DNA replication and the potential for developing specific diagnostic tools and therapeutic strategies.

Collaborations

Mark has collaborated with notable colleagues, including Nathaniel Heintz and Lisa A Dailey. Their combined expertise has contributed to advancements in the understanding of protein complexes and their applications in medicine.

Conclusion

Mark S Caddle's innovative work in the field of molecular biology, particularly with his replication initiator protein complex, showcases his contributions to science and medicine. His research holds promise for future diagnostic and therapeutic developments.