Company Filing History:
Years Active: 1990-1995
Title: The Innovations of Mark M. Zukowski
Introduction
Mark M. Zukowski is a notable inventor based in Thousand Oaks, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of subtilisin analogs. With a total of 5 patents to his name, Zukowski's work has had a considerable impact on cleaning compositions and enzymatic stability.
Latest Patents
Zukowski's latest patents include innovative methods for creating thermally stable and pH stable subtilisin analogs. One of his key inventions involves a mutated subtilisin that is suitable for admixture to washing compositions. This subtilisin exhibits substantially improved stability over naturally occurring Bacillus serine proteases. The method involves expressing a modified gene encoding subtilisin in Bacillus subtilis. A preferred subtilisin analog product differs from wild-type Bacillus alkaline proteases by having any amino acid, preferably serine, at position 218 in place of asparagine. This product is produced in a strain of B. subtilis that is mutated to block the synthesis of endogenous proteases. Additionally, the method of replacing an Asn or a Gly in an Asn-Gly sequence to improve pH and thermal stability can be applied to other sites in subtilisin and to other proteins as well.
Career Highlights
Zukowski is currently employed at Amgen Inc., where he continues to innovate and develop new technologies. His work has been instrumental in advancing the field of enzymatic applications in various industries.
Collaborations
Some of his notable coworkers include Yitzhak Stabinsky and Michael Levitt, who have collaborated with him on various projects.
Conclusion
Mark M. Zukowski's contributions to biotechnology and enzymatic stability are noteworthy. His innovative patents and ongoing work at Amgen Inc. continue to influence the industry positively.