This inventor holds 3 USPTO granted patents. Top assignees: The Rockefeller University, Amgen Inc.. Active years: 1997-1999.
Company Filing History:
3 out of 750 
1 out of 2,065 
Years Active: 1997-1999
Title: Mark M Wurfel: Innovator in Lipopolysaccharide Neutralization
Introduction
Mark M Wurfel is a notable inventor based in New York, NY (US). He has made significant contributions to the field of medical science, particularly in the area of neutralizing lipopolysaccharides. With a total of 3 patents to his name, Wurfel's work has implications for treating gram-negative sepsis.
Latest Patents
One of Wurfel's latest patents focuses on compositions for the neutralization of lipopolysaccharides. This invention relates to compositions and methods for neutralizing lipopolysaccharide and treating gram-negative sepsis. The invention is directed to a composition of homogeneous particles comprising phospholipids and a lipid exchange protein, such as phospholipid transfer protein or LPS binding protein. The lipid exchange protein is characterized by its ability to facilitate the exchange of lipopolysaccharide into the particles. In a specific embodiment, the lipid particles are high-density lipoprotein particles comprising apolipoprotein A-I (apo A-I), a phospholipid, and cholesterol or a lipid bilayer binding derivative thereof. The phospholipid used in this invention is phosphatidylcholine (PC), with a specific ratio of phosphatidylcholine:cholesterol:apolipoprotein A-I being approximately 80:4:1. The levels of LPS exchange protein activity in a sample from a patient provide a diagnostic, monitoring, or prognostic indicator for a subject with endotoxemia, gram-negative sepsis, or septic shock.
Career Highlights
Throughout his career, Wurfel has worked with prestigious organizations, including The Rockefeller University and Amgen Inc. His innovative research has contributed to advancements in medical treatments and diagnostics.
Collaborations
Wurfel has collaborated with notable colleagues such as Samuel D Wright and Peter Eric Hailman. These partnerships have further enhanced the impact of his research in the scientific community.
Conclusion
Mark M Wurfel is a distinguished inventor whose work in lipopolysaccharide neutralization has the potential to improve treatment options for serious medical conditions. His contributions to the field are invaluable and continue to influence ongoing research and development.