Company Filing History:
Years Active: 1999-2001
Title: The Innovative Mind of Mark J Zoller: Pioneering Advances in Protein Kinase Research
Introduction
Mark J Zoller, based in Weston, Massachusetts, is a prominent inventor known for his contributions to the field of protein kinase research. He holds an impressive portfolio of three patents, each reflecting his innovative approach to understanding and manipulating protein interactions. With a career anchored at Ariad Pharmaceuticals, Inc., Zoller continues to make significant strides in scientific research.
Latest Patents
Zoller's latest patents include groundbreaking inventions in the domain of ZAP tyrosine protein kinase. One notable patent focuses on the three-dimensional structure of a ZAP-70 fragment and the associated modeling methods. This invention specifically hones in on the region of ZAP-70 that encompasses the tandem Src homology-2 (SH2) domains. By elucidating the crystalline forms of these regions, both liganded and unliganded, this patent paves the way for designing pharmaceutical compositions aimed at inhibiting the biological functions of ZAP and its related proteins.
Another innovative patent describes an in vitro fluorescence polarization assay. This method assists in identifying substances that inhibit the mutual association of molecules. The assay employs components capable of mutual association, with one part linked to a fluorophore. By measuring the degree of polarization of emitted light post-irradiation, researchers can determine the inhibitory activity of test substances, thereby advancing drug development processes.
Career Highlights
Throughout his career at Ariad Pharmaceuticals, Inc., Mark J Zoller has exemplified dedication to scientific exploration and innovation. His patents not only reflect his ingenuity but also his commitment to addressing complex biological challenges through research.
Collaborations
Zoller's work has been enriched through collaborations with esteemed colleagues such as Berkley A Lynch and Ian MacNeil. These partnerships within the innovative atmosphere of Ariad Pharmaceuticals foster an environment ripe for breakthroughs in pharmaceuticals and biotech research.
Conclusion
Mark J Zoller stands as a remarkable figure in the realm of protein kinase research, with his three patents highlighting his commitment to innovation. His work at Ariad Pharmaceuticals continues to pave the way for advanced pharmaceutical solutions, illustrating the powerful impact of dedicated research and collaboration in addressing pressing health challenges.