Mark Henderson

Title: Mark Henderson: Innovator in Tetrahydrobiopterin Synthesis

Introduction

Mark Henderson is a notable inventor based in Larkspur, California. He has made significant contributions to the field of biochemistry, particularly in the synthesis of tetrahydrobiopterin. With a total of three patents to his name, Henderson's work has implications for both pharmaceutical applications and treatment methodologies.

Latest Patents

Henderson's latest patents include a method of synthesizing tetrahydrobiopterin. This innovative method efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The process involves hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture. This method allows for the separation of the aqueous phase containing biopterin from the organic phase, thus avoiding the time-consuming step of isolating biopterin as a solid. The aqueous solution is then stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under high hydrogen pressure in the presence of a metal catalyst. Additionally, Henderson has developed a stable tablet formulation of tetrahydrobiopterin, which includes processes for producing these formulations and treatment methods utilizing them.

Career Highlights

Throughout his career, Mark Henderson has worked with prominent companies such as BioMarin Pharmaceutical Inc. and The Boeing Company. His experience in these organizations has contributed to his expertise in the field of pharmaceuticals and biochemistry.

Collaborations

Henderson has collaborated with notable coworkers, including Steven Jungles and Robert Baffi. These partnerships have likely enhanced his research and development efforts in the synthesis of tetrahydrobiopterin.

Conclusion

Mark Henderson's innovative work in the synthesis of tetrahydrobiopterin showcases his significant contributions to biochemistry and pharmaceuticals. His patents reflect a commitment to advancing treatment methodologies and improving pharmaceutical formulations.