This inventor holds 5 USPTO granted patents. Top assignee: Osiris Therapeutics, Inc.. Active years: 1999-2006.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Location History:
- Forest Hills, MD (US) (1999)
- Forest Hill, MD (US) (2000 - 2006)
Company Filing History:
Years Active: 1999-2006
Title: Mark A. Thiede and His Contributions to Stem Cell Research.
Introduction
Mark A. Thiede is an inventor associated with Forest Hill, Maryland, and Osiris Therapeutics, Inc. His patent work focuses on using human mesenchymal stem cells to influence the differentiation of hematopoietic stem cells and progenitor cells.
Latest Patents
Thiede’s patent portfolio includes 5 patents. Two of his described inventions explore how mesenchymal stem cells can support or regulate the development of other blood-forming cells.
“Production of Megakaryocytes by the Use of Human Mesenchymal Stem Cells” describes co-culturing hematopoietic progenitor cells with human mesenchymal stem cells to promote megakaryocyte differentiation and platelet production. The invention also addresses genetically engineering hematopoietic stem cells to express physiologically active proteins, with potential applications in modulating blood disorders.
“Regulation of Hematopoietic Stem Cell Differentiation by the Use of Human Mesenchymal Stem Cells” concerns inducing hematopoietic stem cells to differentiate into osteoclasts through co-culture with human mesenchymal stem cells. A preferred embodiment uses no exogenous cytokines. The patent also describes how mesenchymal stem cell differentiation into osteoblasts can inhibit osteoclast differentiation, and how engineered hematopoietic stem cells may express proteins relevant to regulating bone resorption.
Career Highlights
At Osiris Therapeutics, Inc., Thiede’s patent work addressed cell-culture methods and stem-cell differentiation. The inventions connect laboratory techniques with potential therapeutic applications involving platelet production, blood disorders, and bone resorption.
Collaborations
Pankaj Qasba and Gabriel Mbalaviele are identified as Thiede’s coworkers. Their association reflects the collaborative research environment surrounding his work at Osiris Therapeutics, Inc.
Conclusion
Mark A. Thiede’s patents highlight approaches to directing stem-cell differentiation and exploring its potential relevance to blood and bone-related conditions.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile