Mario N Lioubin

Title: The Innovations of Mario N Lioubin

Introduction

Mario N Lioubin is a notable inventor based in Bellevue, WA (US). He has made significant contributions to the field of biotechnology, particularly in the area of growth factors and their applications in medical research. With a total of 3 patents, his work has garnered attention for its potential impact on health and disease treatment.

Latest Patents

Lioubin's latest patents include groundbreaking research on the normal human growth regulatory receptor for TGF-β. His work identifies and purifies the type III TGF-β receptor from normal human embryonic palatal mesenchyme (HEPM) cells. The purified product has been characterized both structurally and functionally. HEPM cells express high levels of this receptor, which significantly down-regulates two classes of TGF-β receptor binding sites. The purification process yielded a biologically active protein of approximately 205 kd, which specifically binds to both recombinant and natural forms of TGF-β1 and TGF-β2, demonstrating high affinity in the picomolar range.

Another significant patent involves an in vitro method of inhibiting HIV using transforming growth factor-β. This patent describes the use of TGF-β to inhibit HIV infection and replication. Both mature and precursor forms of TGF-β have been shown to effectively inhibit HIV production. The TGF-β used for this purpose can be sourced from natural origins or produced through recombinant DNA or chemical synthetic techniques. Additionally, hybrid TGF-β1/β2 molecules may also be utilized in this innovative approach.

Career Highlights

Lioubin is currently associated with Oncogen, a company focused on advancing cancer research and therapies. His work at Oncogen has allowed him to explore the therapeutic potential of growth factors in various medical applications. His innovative research has positioned him as a key figure in the biotechnology sector.

Collaborations

Some of his notable coworkers include Thomas J Brown and Anthony F Purchio. Their collaborative efforts have contributed to the advancement of research in the field of growth factors and their applications.

Conclusion

Mario N Lioubin's contributions to biotechnology through his patents and research have the potential to significantly impact medical science. His innovative work continues to pave the way for new therapeutic approaches in treating diseases such as HIV.