Company Filing History:
Years Active: 2007
Title: Innovations in Biochemical Screening: The Contributions of Marina Veronesi
Introduction
Marina Veronesi is a notable inventor based in Milan, Italy. She has made significant contributions to the field of biochemical screening, particularly through her innovative patent in NMR spectroscopy. Her work has implications for drug-lead discovery, enhancing the efficiency and effectiveness of high-throughput screening methods.
Latest Patents
Marina Veronesi holds a patent for "Fluorine NMR spectroscopy for biochemical screening." This method focuses on high-throughput screening (HTS) of large compound libraries, which is essential for drug-lead discovery. The patent emphasizes that quality is more important than quantity in functional assays. The biochemical NMR method she has developed extends the original work proposed by Percival and Withers, allowing for the screening of Ser/Thr kinases. The technique requires a CF moiety on the substrate and utilizes fluorine NMR spectroscopy to detect both starting and enzymatically modified substrates. Experiments can be conducted in real-time or in an endpoint assay format, using protein and substrate concentrations comparable to other HTS techniques. Her application of this technique to the phosphorylation of a substrate by the protein Ser/Thr kinase AKT1 showcases its practical utility.
Career Highlights
Throughout her career, Marina has worked with prominent companies in the pharmaceutical industry. Notably, she has been associated with Pfizer Italia S.r.l. and Nerviano Medical Sciences S.r.l. These experiences have allowed her to apply her innovative methods in real-world settings, contributing to advancements in drug discovery.
Collaborations
Marina has collaborated with esteemed colleagues, including Claudio Dalvit and Elena Ardini. These partnerships have fostered a collaborative environment that enhances the development and application of her innovative techniques.
Conclusion
Marina Veronesi's contributions to biochemical screening through her patent in fluorine NMR spectroscopy represent a significant advancement in drug-lead discovery. Her work continues to influence the field, demonstrating the importance of innovation in scientific research.