Marina T Larson

Title: Innovations by Marina T Larson

Introduction

Marina T Larson is a prominent inventor based in Silverthorne, Colorado. She has made significant contributions to the field of genetics and molecular biology, holding a total of eight patents. Her work focuses on innovative methods for sequencing nucleic acids and the development of micro-electrophoresis technology.

Latest Patents

One of her latest patents is a method for sequencing nucleic acid polymers. This method allows for the sequencing of a selected region of a target nucleic acid polymer in a natural abundance DNA sample within a single vessel. The process involves combining the sample with a sequencing mixture that includes a primer pair, a thermally stable polymerase, nucleotide feedstocks, and a chain-terminating nucleotide. The reaction mixture also incorporates an unconventional nucleotide and an appropriate enzyme for degradation of nucleic acid polymers containing this unconventional nucleotide. The mixture undergoes multiple thermal cycles for annealing, extension, and denaturation, ultimately producing a product mixture that is analyzed by electrophoresis.

Another notable patent is for a micro-electrophoresis chip designed for moving and separating nucleic acids and other charged molecules. This chip features a substrate with one or more channels, each channel extending approximately 1 cm in length and measuring between 1 to 10 micrometers in width and depth. The channels are filled with a homogeneous separation matrix that impedes the electrophoretic migration of charged molecules. Microelectrodes within the channels induce an electric field, allowing charged molecules to move and separate based on various factors. The chip may also include detectors and sites for enzymatic or chemical manipulation of the separated molecules.

Career Highlights

Marina T Larson is currently employed at Visible Genetics Inc., where she continues to advance her research and innovations in genetic sequencing technologies. Her work has positioned her as a key figure in the field, contributing to the development of cutting-edge solutions for genetic analysis.

Collaborations

Some of her notable coworkers include James Leushner and May Hui, who collaborate with her on various projects within the company.

Conclusion

Marina T Larson's contributions to the field of genetics through her innovative patents and work at Visible Genetics Inc. highlight her role as a leading inventor in molecular biology. Her advancements in nucleic acid sequencing and micro-electrophoresis technology continue to impact the scientific community significantly.