Location History:
- Suita, JP (2012 - 2014)
- Osaka, JP (2015)
Company Filing History:
3 out of 49 
1 out of 987 
1 out of 2 
Years Active: 2012-2015
Title: Mariko Shiba: Innovator in Therapeutic Oligonucleotides
Introduction
Mariko Shiba is a prominent inventor based in Suita, Japan. She has made significant contributions to the field of therapeutic agents, particularly in the development of oligonucleotides. With a total of three patents to her name, her work focuses on innovative solutions for health-related challenges.
Latest Patents
One of her latest patents is an oligonucleotide and therapeutic agent for dyslipidemia. This invention aims to provide an oligonucleotide that exhibits excellent binding affinity to the PCSK9 gene, ensuring stability and safety. The oligonucleotide contains a sugar-modified nucleoside with a bridging structure between the 4'-position and 2'-position, allowing it to effectively bind to the human PCSK9 gene. Additionally, the therapeutic agent includes the oligonucleotide as an active ingredient and preferably utilizes a bioabsorbable material, such as atelocollagen or peptide gel, as a carrier.
Another notable patent involves a drug designed to suppress pathogens occurring in vivo. This invention focuses on a compound that consists of an adsorbent for pathogens found in the blood or lymph, along with a ligand specific to an organ or cells capable of metabolizing or excreting the pathogen. This innovative approach aims to enhance the body's ability to manage harmful pathogens effectively.
Career Highlights
Mariko Shiba has worked with esteemed institutions such as the National Cerebral and Cardiovascular Center and Osaka University. Her experience in these organizations has allowed her to collaborate with leading experts in her field and contribute to groundbreaking research.
Collaborations
Throughout her career, Mariko has collaborated with notable colleagues, including Tetsuji Yamaoka and Satoshi Obika. These partnerships have further enriched her research and development efforts.
Conclusion
Mariko Shiba's innovative work in the field of therapeutic oligonucleotides showcases her dedication to advancing medical science. Her patents reflect a commitment to addressing critical health issues through cutting-edge research and collaboration.