Marie J Bettman

Title: Marie J Bettman: Innovator in Pharmaceutical Formulations

Introduction

Marie J Bettman is a notable inventor based in Clayton, OH (US). She has made significant contributions to the field of pharmaceuticals, particularly in the development of modified release formulations for medications. Her work is especially focused on treatments for attention deficit hyperactivity disorder (ADHD).

Latest Patents

Marie J Bettman holds 1 patent for her invention titled "Methylphenidate modified release formulations." This innovative pharmaceutical formulation is designed as a multiparticulate dosage form, specifically a once-a-day MR Capsule of Methylphenidate. It is indicated for the treatment of children with ADHD and is capable of delivering a portion of the dose for rapid onset of action, while the remainder is released in a controlled manner over approximately 12 hours. The formulation consists of multicoated particles made from two populations of drug-layered beads: immediate release (IR) and extended release (ER) beads. The IR beads are created by layering an aqueous solution containing the drug and a binder onto non-pareil sugar spheres, followed by a seal coat. The ER beads are produced by applying an extended release coating of a water-insoluble dissolution rate-controlling polymer, such as ethylcellulose, to the IR beads. The manufacturing process of the MR Capsules involves filling the IR and ER beads in a specific ratio, which was determined through extensive clinical investigations and in vitro-in vivo correlations in accordance with FDA guidelines.

Career Highlights

Marie J Bettman is associated with Eurand America, Inc., where she has been instrumental in advancing pharmaceutical formulations. Her expertise in the field has led to the development of innovative solutions that enhance patient compliance and treatment efficacy.

Collaborations

Throughout her career, Marie has collaborated with notable colleagues, including Phillip J Percel and Dan L Hensley. These collaborations have contributed to the successful development of her patented formulations.

Conclusion

Marie J Bettman is a pioneering inventor whose work in modified release pharmaceutical formulations has made a significant impact on the treatment of ADHD in children. Her innovative approach and dedication to research continue to influence the pharmaceutical industry.