Marianne Bronner

Title: Innovations of Marianne Bronner in CRISPR Technology

Introduction

Marianne Bronner is a prominent inventor based in La Canada, California, known for her significant contributions to the field of biotechnology, particularly in CRISPR technology. With a total of three patents to her name, Bronner has been at the forefront of developing innovative solutions that enhance the precision and effectiveness of gene editing.

Latest Patents

One of her latest patents focuses on allosteric conditional guide RNAs (cgRNAs) for cell-selective regulation of CRISPR/Cas. This invention plays a crucial role in the CRISPR revolution by allowing programmable control over the regulatory scope of gene editing. The cgRNA's activity is dependent on the presence or absence of an RNA trigger, enabling targeted regulation of CRISPR/Cas functions. Unlike standard guide RNAs, cgRNAs can be programmed at multiple levels, allowing for independent design of target and trigger sequences. This flexibility provides researchers with the ability to select regulatory targets and scopes independently. The disclosed allosteric cgRNA mechanisms facilitate both ON→OFF and OFF→ON logic, allowing for conditional activation or inactivation by an RNA trigger. This innovation enables the restriction of CRISPR/Cas functions to specific cell types, tissues, organs, or disease states, making it a versatile platform for research tools, biotechnologies, diagnostics, and therapeutics.

Career Highlights

Marianne Bronner is affiliated with the California Institute of Technology, where she continues to advance her research in gene editing technologies. Her work has garnered attention for its potential applications in various fields, including medicine and biotechnology.

Collaborations

Throughout her career, Bronner has collaborated with notable colleagues such as Lisa Hochrein and Mikhail H Hanewich-Hollatz, contributing to the advancement of innovative research in her field.

Conclusion

Marianne Bronner's contributions to CRISPR technology through her innovative patents highlight her role as a leading inventor in biotechnology. Her work not only enhances the capabilities of gene editing but also opens new avenues for research and therapeutic applications.