Company Filing History:
Years Active: 1989-1991
Title: The Innovative Contributions of Marian N Beremand
Introduction
Marian N Beremand is a notable inventor based in Peoria, IL (US). He has made significant contributions to the field of biotechnology, particularly in the production of trichothecenes, which are important for cancer therapy research. With a total of 3 patents to his name, Beremand's work has implications for the development of immunotoxins.
Latest Patents
Beremand's latest patents include a method for producing trichothecenes through the addition of L-leucine to the fermentation medium of Fusarium mutant NRRL 18365. This method increases the production of the trichothecenes neosolaniol, 8-propionyl-neosolaniol, and 8-isobutyryl-neosolaniol, which are useful as toxins for the production or investigation of immunotoxins for cancer therapy. Another significant patent involves the selection of mutants blocked or altered in the production of the trichothecene mycotoxin T-2, following UV mutagenesis of Fusarium sporotrichioides NRRL 3299. One of these mutants, NRRL 18339, accumulates the rare trichothecenes dideacetylcalonectrin and deacetylcalonectrin, while another mutant, NRRL 18340, accumulates trichodiene, the first intermediate in the trichothecene biosynthetic pathway. These compounds serve as useful toxins or toxic precursors for immunotoxin research.
Career Highlights
Beremand's career has been marked by his innovative approaches to biotechnology and his dedication to advancing cancer therapy research. His work has not only contributed to scientific knowledge but has also paved the way for potential therapeutic applications.
Collaborations
Throughout his career, Beremand has collaborated with notable colleagues, including Patricia J Black and Frank L VanMiddlesworth. These collaborations have further enhanced the impact of his research and innovations.
Conclusion
Marian N Beremand's contributions to the field of biotechnology, particularly in the production of trichothecenes, highlight his role as an influential inventor. His patents and collaborative efforts continue to advance the understanding and potential treatment of cancer.