Maria I New

Title: Maria I New: Innovator in Steroid Detection and Genetic Probes

Introduction

Maria I New is a prominent inventor based in New York, NY (US), known for her significant contributions to the field of genetic probes and steroid detection. With a total of 3 patents to her name, she has made remarkable advancements that have implications in both medical diagnostics and industrial applications.

Latest Patents

One of her latest patents involves a genetic probe used in the detection of adrenal hyperplasia. This innovation includes a cDNA clone that encodes a bovine adrenal cytochrome P-450 specific for steroid 21-hydroxylation. The plasmid pC21a contains an insert of 520 base pairs and hybridizes with mRNA encoding P-450.sub.C21. The peptide encoded by this insert shows high homology to peptides isolated from porcine P-450.sub.C21 and limited homology to the P-450 induced by phenobarbital in rat liver. This probe, along with its human equivalents, can be utilized to screen both pre-natal and post-natal patients for adrenal hyperplasia, as it reacts effectively with human DNA. Additionally, these probes can be beneficial for industrial fermentation processes aimed at producing cortisone in large quantities.

Another significant patent is a method for determining steroids in human body liquids. This method allows for the determination of steroids such as dehydroepiandrosterone sulfate (DS) in human body liquid samples. The process involves transferring the liquid sample to a sheet of microfilter paper, drying it, and then treating it with an aqueous solvent to create a mixture. The mixture is then contacted with an aqueous solution of an agent that selectively binds the steroid in the presence of a radioisotopically labeled form of the steroid. This innovative method enables the separation of bound steroids from unbound steroids, allowing for the determination of hormone concentration based on measured radioactivity.

Career Highlights

Throughout her career, Maria I New has worked with notable organizations, including the Cornell Research Foundation Inc. Her work has significantly impacted the fields of genetics and endocrinology, showcasing her expertise and dedication to advancing scientific knowledge.

Collaborations

Maria has collaborated with esteemed colleagues, including Songja Pang and Perrin C White, further enhancing her research and contributions to the scientific community.

Conclusion

Maria