Location History:
- San Bruno, CA (US) (2004)
- Davis, CA (US) (2006)
Company Filing History:
Years Active: 2004-2006
Title: Maria C Roque-Biewer: Innovator in Fluorescent Polynucleotide Separation
Introduction
Maria C Roque-Biewer is a distinguished inventor based in Davis, CA (US). She has made significant contributions to the field of biotechnology, particularly in the calibration of fluorescent polynucleotide separation apparatus. With a total of 2 patents, her work has advanced the methods and systems used in genetic analysis.
Latest Patents
One of her latest patents focuses on the spectral calibration of fluorescent polynucleotide separation apparatus. This invention relates to methods, compositions, and systems for calibrating such apparatus. A key aspect of this invention is the development of multiple color calibration standards, which are mixtures of at least two polynucleotides of different lengths, each labeled with a spectrally distinct fluorescent dye. The invention also includes the production of total emission temporal profiles of these calibration standards, which are essential for accurate calibration. The peaks corresponding to the fluorescently labeled polynucleotides can be detected using a peak detector that responds to changes in the slopes of the total emission temporal profile.
Another important aspect of her invention involves the identification of labeled polynucleotides within the multiple color calibration standards. The process of spectral calibration may also include estimating the dyes' reference spectra, utilizing information from the peak detection process. Furthermore, her work encompasses systems designed for separating and detecting fluorescently labeled polynucleotides, which are crucial for effective spectral calibration.
Career Highlights
Maria C Roque-Biewer is associated with Applera Corporation, where she continues to innovate in her field. Her expertise in fluorescent polynucleotide separation has positioned her as a key figure in biotechnology research and development.
Collaborations
She collaborates with notable professionals in her field, including Muhammad A Sharaf, enhancing the impact of her inventions through teamwork and shared expertise.
Conclusion
Maria C Roque-Biewer's contributions to the field of biotechnology, particularly in the calibration of fluorescent polynucleotide separation apparatus, demonstrate her innovative spirit and commitment to advancing genetic analysis technologies. Her work continues to influence the industry and pave the way for future advancements.