Margret Nathan

Title: Margret Nathan: Innovator in Human Serum Albumin Expression Constructs

Introduction

Margret Nathan is a notable inventor based in West Chester, PA (US). She has made significant contributions to the field of biotechnology, particularly in the development of DNA constructs for human serum albumin expression.

Latest Patents

Margret Nathan holds a patent for a "Human serum albumin expression construct." This invention provides DNA constructs that include a promoter DNA sequence and a DNA sequence coding for human serum albumin. In one embodiment, the human serum albumin sequence comprises at least one, but not all, of the introns found in the naturally occurring gene encoding the HSA protein. Additionally, the constructs may include a 5' regulatory sequence that directs the expression and secretion of HSA protein in the milk of a transgenic animal. The promoter gene is preferably a milk protein promoter sequence, such as β-lactoglobulin. This invention also encompasses transgenic animals that secrete HSA in the milk of lactating females, as well as vectors that comprise the constructs.

Career Highlights

Throughout her career, Margret Nathan has worked with prominent companies in the pharmaceutical and biotechnology sectors. Notable among these are Rhone-Poulenc Rorer Pharmaceuticals Inc. and Peri Development Applications (1985) Ltd. Her work has significantly advanced the understanding and application of human serum albumin in medical and research settings.

Collaborations

Margret has collaborated with esteemed colleagues, including David R. Hurwitz and Moshe Shani. These partnerships have contributed to her innovative work and the successful development of her patented technologies.

Conclusion

Margret Nathan's contributions to the field of biotechnology, particularly through her patent on human serum albumin expression constructs, highlight her role as a pioneering inventor. Her work continues to influence advancements in medical research and applications.