Company Filing History:
Years Active: 1994-1997
Title: Margit Ann Gayle: Innovator in Therapeutic Antibody-Based Fusion Proteins
Introduction
Margit Ann Gayle is a prominent inventor based in Woodinville, WA (US). She has made significant contributions to the field of biotechnology, particularly in the development of therapeutic antibody-based fusion proteins. With a total of 2 patents, her work focuses on enhancing antitumor immune responses through innovative methods.
Latest Patents
Margit Ann Gayle's latest patents include groundbreaking inventions that utilize antibody-based fusion proteins. One of her notable patents is centered on therapeutic antibody-based fusion proteins, which aim to provide a targeted and amplified antitumor immune response. This invention involves the use of an immunoglobulin portion that binds to tumor antigens, linked to a biologically active lymphokine. The immunoglobulin portion directs the fusion protein to tumor cells, while the lymphokine stimulates the proliferation of immune T cells, thereby enhancing the anti-tumor immune response. In preferred embodiments, the immunoglobulin portion is derived from the L6 monoclonal antibody, and the lymphokine is interleukin-2.
Another significant patent involves therapeutic interleukin-2-antibody-based fusion proteins. This invention describes fusion proteins where a portion of an immunoglobulin molecule is linked to a biologically active ligand. Specifically, the fusion protein comprises a portion of an antibody that recognizes a cell surface antigen linked to a lymphokine or cellular factor. A preferred embodiment includes the variable region of the anti-tumor monoclonal antibody L6 and an active lymphokine molecule such as IL-2.
Career Highlights
Margit Ann Gayle has established herself as a key figure in the biotechnology sector. Her innovative work has led to advancements in cancer treatment methodologies, showcasing her commitment to improving therapeutic options for patients.
Collaborations
Margit collaborates with Henry Perry Fell, Jr., further enhancing her research and development efforts in the field of therapeutic proteins.
Conclusion
Margit Ann Gayle's contributions to the field of biotechnology through her patents on therapeutic antibody-based fusion proteins highlight her innovative spirit and dedication to advancing cancer treatment. Her work continues to pave the way for new therapeutic strategies that could significantly impact patient care.