Margie Tabuga Borra-Garske

Margie Tabuga Borra-Garske is a prominent inventor based in Palo Alto, California. She has made significant contributions to the field of biochemical engineering, particularly in the development of engineered enzymes. With a total of nine patents to her name, her work has implications for pharmaceutical production and biotechnology.

Latest Patents

One of her latest patents involves polynucleotides encoding engineered acetate kinase variant enzymes. This invention provides engineered acetate kinase (AcK) enzymes, polypeptides with AcK activity, and polynucleotides encoding these enzymes. It also includes vectors and host cells that comprise these polynucleotides and polypeptides. The methods for producing AcK enzymes are particularly noteworthy, as they find applications in the production of pharmaceutical compounds. Another significant patent focuses on engineered cyclic GMP-AMP synthase (cGAS) variant enzymes. These enzymes have been designed to produce polypeptides with increased cGAS activity, which is crucial for the cyclization of modified nucleoside triphosphates. This invention also includes methods for producing cGAS enzymes and compositions that utilize these engineered enzymes for pharmaceutical applications.

Career Highlights

Margie currently works at Codexis, Inc., where she continues to innovate in the field of enzyme engineering. Her work has not only advanced scientific understanding but has also contributed to practical applications in medicine and biotechnology.

Collaborations

Margie collaborates with talented individuals such as Oscar Alvizo and Lillian Jasmine Miller, enhancing the innovative environment at Codexis, Inc.

Conclusion

Margie Tabuga Borra-Garske is a trailblazer in biochemical engineering, with a focus on developing engineered enzymes that have significant pharmaceutical applications. Her contributions are paving the way for advancements in biotechnology and medicine.

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