Margaretha Olthoff

Title: Margaretha Olthoff: Innovator in Pharmaceutical Composition

Introduction

Margaretha Olthoff is a notable inventor based in Leiderdorp, Netherlands. She has made significant contributions to the field of pharmaceuticals, particularly in the development of solid dosage forms of bendamustine. With a total of 3 patents to her name, her work has the potential to impact the treatment of various medical conditions.

Latest Patents

One of her latest patents is focused on solid dosage forms of bendamustine. This invention provides a pharmaceutical composition suitable for oral administration, comprising bendamustine or a pharmaceutically acceptable ester, salt, or solvate as an active ingredient. The composition also includes at least one pharmaceutically acceptable excipient, specifically a saccharide, with a defined weight ratio of active ingredient to excipient. Another significant patent involves oral dosage forms of bendamustine, which ensures a dissolution rate of at least 60% in 20 minutes, 70% in 40 minutes, and 80% in 60 minutes. This formulation is designed for the oral treatment of various medical conditions, including chronic lymphocytic leukemia and breast cancer.

Career Highlights

Margaretha Olthoff is currently associated with Astellas Deutschland GmbH, where she continues to innovate in the pharmaceutical sector. Her work is characterized by a commitment to improving drug formulations and enhancing patient outcomes.

Collaborations

Throughout her career, she has collaborated with notable colleagues such as Jeffrey Colledge and Thomas Alfred Profitlich. These partnerships have contributed to her success and the advancement of her research.

Conclusion

Margaretha Olthoff is a pioneering inventor whose work in pharmaceutical compositions is making a difference in the medical field. Her contributions, particularly in the area of bendamustine formulations, highlight her dedication to innovation and improving healthcare solutions.