Location History:
- East Brunswick, NJ (US) (1995 - 1996)
- E. Brunswick, NJ (US) (1996 - 1997)
Company Filing History:
Years Active: 1995-1997
Title: Innovations and Contributions of Inventor Margaret H Lai
Introduction
Margaret H Lai is a notable inventor based in East Brunswick, NJ (US). She has made significant contributions to the field of biochemistry, particularly in the area of sterol biosynthesis. With a total of 4 patents to her name, her work has implications for both fungicide development and cholesterol management.
Latest Patents
One of her latest patents is titled "Sterol .DELTA.14 reductase screen." This invention involves a binary assay that identifies agents inhibiting sterol .DELTA.14 reductase, which is crucial in ergosterol biosynthesis. The primary screen assesses the inhibition of sterol .DELTA.14 reductase by comparing growth inhibition in cultures of Neurospora crassa with different mutations. The secondary screen further validates positive samples by observing growth inhibition in cultures with and without the introduced reductase gene. This method is highly sensitive and specific for detecting sterol .DELTA.14 reductase inhibitors.
Another significant patent is the "Enzyme induction screen for ergosterol biosynthesis inhibitors." This method screens for potential fungicides or antihypercholesterolemic agents by inducing lanosterol 14-.alpha.-demethylase in cultures. The increase in enzyme activity is measured indirectly through .beta.-galactosidase activity, allowing for the identification of active samples based on color production in the culture media.
Career Highlights
Margaret H Lai has been associated with the American Cyanamid Company, where she has applied her expertise in biochemistry to develop innovative solutions. Her work has not only advanced scientific understanding but also contributed to practical applications in medicine and agriculture.
Collaborations
Throughout her career, Margaret has collaborated with esteemed colleagues, including Donald R Kirsch and Martin Bard. These partnerships have fostered a collaborative environment that enhances research and innovation.
Conclusion
Margaret H Lai's contributions to the field of biochemistry through her patents and collaborations highlight her role as a significant inventor. Her work continues to influence the development of important biotechnological applications.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.