This inventor holds 1 USPTO granted patent and 4 published patent applications. Top assignee: University of Kansas. Active years: 2014.
Company Filing History:
Years Active: 2014
Title: Innovations in Drug Delivery by Marcus Laird Forrest
Introduction
Marcus Laird Forrest is an innovative inventor based in Lawrence, KS (US). He has made significant contributions to the field of drug delivery systems, particularly through his unique polymer compositions. His work focuses on enhancing the efficacy of drug and imaging agent delivery in vivo.
Latest Patents
Marcus Laird Forrest holds a patent for "Drug and imaging agent delivery compositions and methods." This invention features a multi-arm, star-shaped polymer composition designed for drug delivery and imaging applications. The star polymer architecture can be synthesized using advanced living radical polymerization techniques. These include reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates under various reaction conditions and functional groups. The star-shaped polymeric carriers are specifically tailored for the preferential delivery of chemotherapeutics into tumor-draining lymphatics through subcutaneous, peritumoral, or intratumoral injections. The carriers can be loaded with chemotherapeutic agents ranging from about 10% to about 25% w/w, and imaging agents from about 5% to about 10% w/w. The molecular weights of these polymeric carriers can vary from about 40 kDa to about 130 kDa. The chemotherapeutics utilized can include cisplatin, geldanamycin, or nitric oxide-donating prodrugs, while the imaging agent may be a near-infrared dye, such as IR820.
Career Highlights
Marcus Laird Forrest is affiliated with the University of Kansas, where he continues to advance his research in drug delivery systems. His innovative approach to polymer design has the potential to significantly improve therapeutic outcomes for patients undergoing chemotherapy.
Collaborations
He has collaborated with notable colleagues, including Daniel J Aires and Shaofeng Duan, to further enhance the impact of his research in the field.
Conclusion
Marcus Laird Forrest's contributions to drug delivery innovations exemplify the intersection of chemistry and medicine. His patented work on star-shaped polymer compositions represents a significant advancement in the field, promising improved delivery methods for critical therapeutic agents.