Marcus J Plaum

Title: Innovations of Marcus J Plaum

Introduction

Marcus J Plaum is a notable inventor based in Sittard, Netherlands. He has made significant contributions to the field of chemistry, particularly in the development of processes for synthesizing complex organic compounds. With a total of two patents to his name, Plaum's work showcases his expertise and innovative approach to chemical synthesis.

Latest Patents

Plaum's latest patents include a process for preparing optically active 2-amino-.omega.-oxoalkanoic acid. This process involves converting the corresponding aldehyde into an acetal-protected aldehyde, which is then transformed into an aminonitrile. The aminonitrile is subsequently converted into an amino acid amide, which undergoes enzymatic, enantioselective hydrolysis to isolate the (S)-amino acid. Another significant patent is for the preparation of a benzothiazepine derivative. This process entails subjecting a propanoic acid derivative to an intramolecular cyclization reaction in a non-halogenated solvent, leading to the formation of pharmaceutical products, particularly diltiazem.

Career Highlights

Marcus J Plaum is associated with DSM N.V., a company known for its focus on health, nutrition, and materials. His work at DSM N.V. has allowed him to contribute to advancements in pharmaceutical chemistry and organic synthesis.

Collaborations

Plaum has collaborated with notable coworkers such as Wilhemus H Boesten and Quirinus B Broxterman. Their combined expertise has likely enhanced the innovative processes developed in their respective fields.

Conclusion

Marcus J Plaum's contributions to the field of chemistry through his patents reflect his innovative spirit and dedication to advancing chemical synthesis. His work continues to impact the pharmaceutical industry positively.