Marco DeLiso

Title: Marco DeLiso: Patent Innovation in pH Probe Calibration

Introduction

Marco DeLiso is an inventor based in Thousand Oaks, California, whose patent work addresses process verification in biopharmaceutical manufacturing. His invention focuses on checking the calibration status of pH probes during low-pH viral inactivation.

Latest Patents

DeLiso is associated with 1 patent, titled “In-process verification of calibration status of pH probes.” The patent describes an automated process for treating an elution pool to reduce viral concentration while checking pH probe performance.

In the process, an elution pool and acid are added to a first vessel. Once pH probes indicate that the pool has reached a sufficiently low pH, it is transferred to a second vessel and checked again. The pool is held for a period intended to reduce viral concentration, then neutralized, filtered, and transferred to a third vessel.

While the pool is being processed, the first vessel is filled with a buffer of known pH. Its measured pH is compared with the first vessel’s probe readings to determine whether recalibration is needed. After the pool leaves the second vessel, that vessel is similarly checked using a known-pH buffer. The sequence can then repeat with a new elution pool.

Career Highlights

DeLiso’s patent reflects an approach to integrating equipment verification into a manufacturing workflow. By checking probe readings between processing stages, the method is designed to help identify when recalibration may be necessary without separating verification from the production sequence.

Collaborations

DeLiso is associated with Amgen Inc. The patent lists Venkatesh Natarajan and Jeremy Aaron Bezaire among his coworkers.

Conclusion

Marco DeLiso’s patent combines low-pH viral inactivation with in-process pH probe verification, highlighting a practical innovation for monitoring calibration during biopharmaceutical manufacturing.