Marcelo B Sztein

Title: Innovations and Contributions of Inventor Marcelo B Sztein

Introduction

Marcelo B Sztein is a prominent inventor based in Columbia, MD (US), known for his significant contributions to the field of immunology and tissue engineering. With a total of three patents to his name, Sztein has made remarkable strides in developing innovative methods and constructs that advance medical research and therapeutic applications.

Latest Patents

One of Sztein's latest patents is the "Multicellular organotypic model of human intestinal mucosa." This patent discloses methods for preparing multi-cellular three-dimensional tissue constructs that include fibroblasts, endothelial cells, lymphocytes, and epithelial cells. The methods involve embedding fibroblasts and endothelial cells in a matrix enriched with gut basement membrane proteins, which is then added to a bioreactor and exposed to epithelial cells and activated lymphocytes. This innovative approach allows for the creation of tissue constructs that can be used to measure toxicity of pathogens, chemosensitivity of tissues, and inflammatory conditions.

Another significant patent is the "Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner." This patent describes methods of using Zot or zonulin as an antigen-specific inhibitor of antigen presenting cell (APC) activity and lymphocyte proliferation. This method is particularly useful in the fields of immunoregulation and immunotherapy, as it down-regulates the immune response in a dose-dependent manner by inhibiting antigen presenting cell-mediated lymphocyte proliferation.

Career Highlights

Sztein is affiliated with the University System of Maryland, where he continues to engage in groundbreaking research. His work focuses on the intersection of immunology and tissue engineering, contributing to advancements that have the potential to improve therapeutic strategies for various diseases.

Collaborations

Throughout his career, Sztein has collaborated with notable colleagues, including Alessio Fasano and Fernando R Noriega. These collaborations have further enriched his research and expanded the impact of his innovations in the scientific community.

Conclusion

Marcelo B Sztein's contributions to the fields of immunology and tissue engineering through his innovative patents highlight his role as a leading inventor. His work not only advances scientific understanding but also paves the way for new therapeutic approaches.