Company Filing History:
Years Active: 1999
Title: Marcel Van Der Rijst: Innovator in Pharmaceutical Chemistry
Introduction
Marcel Van Der Rijst is a notable inventor based in Nijmegen, Netherlands. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of novel methods for drug preparation. His work has led to advancements in the synthesis of important pharmaceutical compounds.
Latest Patents
Marcel Van Der Rijst holds a patent for a process for preparing epirubicin or acid addition salts thereof. This invention relates to a novel method for the chemical preparation of epirubicin, specifically the HCl salt, from daunorubicin. The process he developed avoids the disadvantages of prior art. Initially, daunorubicin is methanolized to obtain daunomycinone and daunosamine methyl ether in very high yields. Daunomycinone is then converted to 14-acetoxy daunomycinone through bromination and acetoxylation, while daunosamine methyl ether is transformed into an N-protected 4'-epi daunosamine. The choice of the protecting group for the amino group of the daunosamine methyl ether is crucial, as it must be removed after coupling the sugar with the aglycone without causing side reactions. Two protecting groups were selected: the trifluoroacetyl group and the allyloxycarbonyl group. After coupling the 14-acetoxy daunomycinone with the N-protected 4'-epi daunosamine, the resulting compound is converted to epirubicin, with two routes developed for this conversion depending on the amino-protecting group.
Career Highlights
Marcel Van Der Rijst is associated with Pharmachemie B.V., where he has been instrumental in advancing pharmaceutical research and development. His innovative approaches have contributed to the efficiency and effectiveness of drug synthesis processes.
Collaborations
He has collaborated with notable colleagues, including Johan W. Scheeren and Dick De Vos, who have also contributed to advancements in pharmaceutical chemistry.
Conclusion
Marcel Van Der Rijst's contributions to the field of pharmaceutical chemistry, particularly through his patent for the preparation of epirubicin, highlight his role as an innovator in drug development. His work continues to influence the pharmaceutical industry and improve drug synthesis methodologies.