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Years Active: 2021-2025
Title: Celebrating the Innovations of Marc-Henri Stern
Introduction
Marc-Henri Stern, an accomplished inventor based in Paris, France, has made significant contributions to the field of biotechnology with a focus on genomic research. With a total of five patents to his name, Stern has advanced methods for detecting mutations and circulating tumor DNA, which have implications for cancer diagnosis and treatment.
Latest Patents
Stern's latest innovations include a patent for a method for detecting a mutation in a microsatellite sequence. This method involves subjecting a DNA sample to a digital polymerase chain reaction (PCR), allowing for precise identification of mutations within the microsatellite sequences.
Another notable patent revolves around the detection of methylated tumor DNA. This method is adept at identifying tumors from cell-free samples, utilizing adjacent methylation signals within sequencing reads to provide accurate tumor signals while minimizing false positives. The process involves extracting DNA from a subject's cell-free sample, converting it with bisulfite, and amplifying cancer-specific methylated regions. This innovation is also beneficial for predicting and monitoring treatment responses, tumor load, and cancer development.
Career Highlights
Marc-Henri Stern has been involved with renowned organizations such as the Institut Curie and the Institut National de la Santé et de la Recherche Médicale. His career at these institutions has been marked by his commitment to advancing cancer genomics and providing novel methods to improve patient outcomes.
Collaborations
Throughout his career, Stern has collaborated with talented professionals such as Elodie Manie and Tatiana Popova. These partnerships have contributed to the success of his projects and innovations in the realm of oncology and molecular diagnostics.
Conclusion
Marc-Henri Stern stands out as a pivotal figure in biotechnology, fostering groundbreaking methods that enhance cancer detection and treatment. With his ongoing innovations and collaborations, he continues to make lasting contributions to the scientific community, demonstrating the power of inventive thinking in addressing critical health challenges.