Manuel Endesfelder

Title: Innovations by Manuel Endesfelder

Introduction

Manuel Endesfelder is a notable inventor based in Wessling, Germany. He has made significant contributions to the field of biochemistry, particularly in the development of methods for measuring antibody interactions with antigens. With a total of 2 patents to his name, Endesfelder's work is paving the way for advancements in immunology.

Latest Patents

Endesfelder's latest patents include innovative methods for determining the binding affinity of antibodies. One patent focuses on the direct affinity measurement of human IgG1 binding to multimeric antigens. This method involves incubating a mixture of the antibody and a specific polypeptide under controlled conditions to cleave the antibody into its components. The binding affinity is then determined using surface plasmon resonance techniques. Another patent details a method for assessing the in vivo interaction mode of antibodies with multimeric antigens, providing insights into whether the binding is affinity-driven or avidity-driven based on comparative binding affinities.

Career Highlights

Manuel Endesfelder is currently employed at Hoffmann-La Roche Inc., where he continues to innovate in the field of antibody research. His work is instrumental in enhancing our understanding of antibody-antigen interactions, which is crucial for the development of therapeutic antibodies.

Collaborations

Endesfelder collaborates with esteemed colleagues such as Joerg Moelleken and Michael Molhoj. Their combined expertise contributes to the advancement of research in immunology and biochemistry.

Conclusion

Manuel Endesfelder's contributions to the field of biochemistry through his patents and research at Hoffmann-La Roche Inc. highlight the importance of innovation in understanding antibody interactions. His work is essential for future developments in therapeutic applications.