This inventor holds 1 USPTO granted patent. Top assignee: University of Colorado. Active years: 2022.
Company Filing History:
Years Active: 2022
Title: Manjunatha Sagar Dodderi: Innovator in Optical DNA Sequencing
Introduction
Manjunatha Sagar Dodderi is a prominent inventor based in Dayton, MN (US). He has made significant contributions to the field of optical DNA sequencing, showcasing his innovative approach to biotechnology.
Latest Patents
Dodderi holds a patent for a groundbreaking invention titled "High-throughput block optical DNA sequence identification." This patent discloses a multiplexed design that utilizes three-dimensional plasmonic nanofocusing and confinement of light. The invention demonstrates reproducible and robust single-molecule optical fingerprints using two complementary vibrational spectroscopy techniques: infrared and Raman spectroscopy. It identifies respective vibrational modes that uniquely fingerprint biomolecular species and facilitates the differentiation of these fingerprints in DNA mixtures, including epigenetic modifications. Although the nanometer scale mode volumes currently prevent single letter identification of DNA sequences, Dodderi presents an alternative method for identifying A, T, G, C DNA nucleotides in 'k-mers.' This method uses sequences of these blocks as a unique and high-throughput alternative to single letter sequences, similar to binary and hexadecimal systems. Furthermore, the additivity shown in single-molecule DNA mixtures and robust optical signatures can be employed in a raster-type step scan to identify single letter sequences. These advancements pave the way for the development of a novel, high-throughput block optical sequencing (BOS) method.
Career Highlights
Dodderi is affiliated with the University of Colorado, where he continues to push the boundaries of research in optical DNA sequencing. His work has garnered attention for its potential applications in various fields, including genetics and molecular biology.
Collaborations
Dodderi collaborates with Prashant Nagpal, contributing to the advancement of their shared research interests in optical technologies and DNA sequencing.
Conclusion
Manjunatha Sagar Dodderi is a visionary inventor whose work in optical DNA sequencing is set to revolutionize the field. His innovative approaches and patented technologies hold great promise for future advancements in biotechnology.