Manikrao Warpe

Title: Innovations of Manikrao Warpe in Pharmaceutical Chemistry

Introduction

Manikrao Warpe is a notable inventor based in Maharashtra, India. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of important compounds used in medication.

Latest Patents

Warpe holds a patent for a process for the preparation of lurasidone and its intermediate. This invention provides an improved method for preparing the substantially pure (3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-1'-ium methanesulfonate, referred to as compound-II. The process involves the reaction of compound-III with compound-IV in the presence of a solvent mixture of alcohol and water, along with a base. This improved method results in a product with less than 0.06% of unreacted compound-IV as an impurity and an HPLC purity of ≥99.8%. Additionally, the process includes the purification of lurasidone hydrochloride, ensuring that the residual acetone is less than 5000 ppm.

Career Highlights

Manikrao Warpe is associated with Piramal Enterprises Limited, a prominent company in the pharmaceutical sector. His work focuses on developing innovative processes that enhance the efficiency and purity of pharmaceutical compounds.

Collaborations

Warpe has collaborated with notable colleagues such as Milind Moreshwar Gharpure and Shashi Kant Tiwari. Their combined expertise contributes to the advancement of pharmaceutical research and development.

Conclusion

Manikrao Warpe's contributions to the field of pharmaceutical chemistry, particularly through his patent on lurasidone synthesis, highlight his innovative spirit and dedication to improving drug development processes. His work continues to impact the pharmaceutical industry positively.