Mangesh Pandurang Dushing

Title: Mangesh Pandurang Dushing: Innovator in Nucleoside Synthesis

Introduction

Mangesh Pandurang Dushing is a notable inventor based in Pune, India. He has made significant contributions to the field of chemistry, particularly in the synthesis of nucleosides. With a total of 2 patents to his name, Dushing's work showcases his innovative approach to chemical synthesis.

Latest Patents

Dushing's latest patents focus on spiroannulated nucleosides and the processes for their preparation. He claims a simple strategy for synthesizing a collection of C(3')-spirodihydroisobenzo-furannulated nucleosides. This involves a [2+2+2]-cyclotrimerization as the key reaction. The cyclotrimerization reactions are facile with unprotected nucleosides that have a diyne unit. When both alkynes of the diyne are terminal, the regioselectivity is poor. However, when one of the terminal alkynes is additionally substituted, the cyclotrimerizations become highly diastereoselective. Since the key bicycloannulation is the final step, this strategy provides flexibility in terms of the alkynes, making it amenable for the synthesis of a focused small molecule library.

Career Highlights

Dushing is affiliated with the Council of Scientific and Industrial Research, where he continues to advance his research in nucleoside synthesis. His work has garnered attention for its innovative methodologies and potential applications in medicinal chemistry.

Collaborations

Dushing collaborates with Venkata Ramana Chepuri, contributing to the advancement of their research projects.

Conclusion

Mangesh Pandurang Dushing is a prominent figure in the field of nucleoside synthesis, with innovative patents that reflect his expertise and creativity. His contributions are paving the way for future advancements in chemical synthesis.