Company Filing History:
2 out of 142 
1 out of 10 Years Active: 2000-2002
Title: Manabu Node: Innovator in Organic Chemistry
Introduction
Manabu Node is a distinguished inventor hailing from Hirakata, Japan, known for his significant contributions to organic chemistry. With a portfolio that includes three patents, Node's work focuses on the synthesis of optically active compounds, showcasing his expertise and innovative approach in the field.
Latest Patents
Manabu Node's recent patents reflect his deep understanding of organic synthesis. One of his notable inventions is a "Process for producing optically active tropinonemonocarboxylic acid derivative." This innovative method involves reacting succindialdehyde with an organic amine and acetonedicarboxylic acid ester to produce a tropinonedicarboxylic acid ester derivative. By employing enzyme-catalyzed asymmetric dealkoxy-carbonylation, Node achieved a yield of 30 to 50 mol % with an optical purity of 70 to 97% ee. The resulting optically active tropinonemonocarboxylic acid ester derivative exhibited the same absolute configuration as natural cocaine.
Additionally, Node developed a method for the "synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof." This inventive process involves preparing an optically active allene-1,3-dicarboxylic acid ester derivative and transforming it through a series of reactions to yield the target compound.
Career Highlights
Throughout his career, Manabu Node has made significant strides in the field of organic chemistry. He has worked at notable companies, including Nihon Medi-Physics Company and Nippon Shoji Kaisha Ltd. His dedication to research and innovation has enabled him to create impactful solutions within his industry.
Collaborations
Node has collaborated with esteemed colleagues such as Daisaku Nakamura and Masakatsu Hisaki. These partnerships have further enhanced his research capabilities and contributed to the successful development of his patented inventions.
Conclusion
Manabu Node is a remarkable inventor whose contributions to organic chemistry are noteworthy. His advanced methods for synthesizing optically active compounds have the potential to influence various applications within the field. With an impressive portfolio of patents and a collaborative spirit, Node continues to push the boundaries of innovation in organic synthesis.
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