This inventor holds 2 USPTO granted patents. Top assignees: Mcgill University, The Hong Kong Polytechnic University. Active years: 2017-2019.
Company Filing History:
2 out of 570 
2 out of 438 
Years Active: 2017-2019
Title: Innovations by Man Chun Law in Cancer Treatment
Introduction
Man Chun Law is an accomplished inventor based in Hong Kong, CN. She has made significant contributions to the field of cancer treatment through her innovative research. With a total of 2 patents, her work focuses on developing compounds that can effectively modulate multidrug resistance in cancer cells.
Latest Patents
One of her latest patents involves the creation of alkyne-, azide-, and triazole-containing flavonoids as modulators for multidrug resistance in cancers. A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides and alkynes. These compounds were screened for their ability to modulate multidrug resistance in various overexpressed cell lines. The results showed promising MDR reversal activity against P-gp-, MRP1-, and BCRP-mediated drug resistance. The compounds displayed different levels of selectivity for various transporters, categorizing them into mono-selective, dual-selective, and multi-selective modulators. The EC50 values for reversing drug resistance were found to be in the nanomolar range, indicating their potential effectiveness. Importantly, many of these compounds exhibited high therapeutic index values, suggesting they are safe MDR chemosensitizers.
Career Highlights
Man Chun Law has worked with prestigious institutions such as The Hong Kong Polytechnic University and McGill University. Her research has significantly advanced the understanding of how to combat drug resistance in cancer therapies.
Collaborations
Some of her notable coworkers include Larry Ming Cheung Chow and Tak Hang Chan, who have contributed to her research endeavors.
Conclusion
Man Chun Law's innovative work in developing flavonoid-based compounds represents a significant advancement in the fight against cancer. Her contributions are paving the way for more effective treatments for patients facing multidrug resistance.